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KMID : 0605720070130020239
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 2 p.239 ~ p.244
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No Association of the -521C/T Polymorphism in the Promoter Region of DRD4 Gene with ADHD
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Yun Jeong-Ju
Kim Dae-Kwang
Jung Chul-Ho
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Abstract
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Objectives: Attention deficit/hyperactivity disorder(ADHD) is known to be the most common childhood psychiatric disorder with high heritability estimates. The dopamine system genes have been the focus of most candidate gene studies of ADHD. Polymorphism displays considerable racial/ethnic heterogeneity. In contrast with previous Western studies, significant association of the -521C/T polymorphism in the promoter region of DRD4 with ADHD was reported in Korean study. We aimed to replicate this finding.
Methods: 107 ADHD patients and 114 normal neonates participated in this study. The genotypes and allele frequency of the -521C/T polymorphism between ADHD patients and controls were compared.
Results: There was no significant difference in genotype(p=0.506) and allele(p=0.252) frequency of the -521C/T polymorphism between ADHD patients and controls.
Conclusion: It suggested that there was no association of the -521C/T polymorphism with ADHD in Korean
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KEYWORD
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ADHD, DRD4, -521C/T polymorphism, Genetic Association study
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